Liberty Blue™ Automated Microwave Peptide Synthesizer

Efficient peptide synthesis system.

Liberty Blue 2.0

Synthesize peptides more efficiently than ever before.

The Liberty Blue™ 2.0 is the exciting next generation of the best-selling peptide synthesizer in the world. Compared to its predecessor, the Liberty Blue 2.0 features the ability to make cleaner and longer peptides with a new level of robustness. The system features a 4-minute cycle time along with a 90% solvent reduction based on High Efficiency Solid Phase Peptide synthesis (HE-SPPS). The Liberty Blue 2.0 features the latest in engineering for fluidic deliveries, true internal temperature feedback control, and software control with 21 CFR Part 11 compliance

Unique Chemistry

  • CarboMAX™ coupling chemistry (patented)
  • Microwave deprotection and coupling (patented)
  • Nitrogen Headspace Flushing (patent pending)


  • 4 min cycle time
  • 90% waste reduction (HE-SPPS)
  • Flex-Add™ critical reagent delivery system (patented)
  • True Internal fiber-optic temperature control
  • 0.005 – 5 mmol scale range
  • 27 amino acid positions
  • Integrated RV Camera
  • High-throughput upgrade options (HT4, HT12)

Unmatched Quality

A new level of peptide purity.

The Liberty Blue 2.0 provides the ability to make even higher purity peptides than previously possible with the original Liberty Blue system. This is based on advances in the system fluidics, reaction vessel environment, and chemistry methodology.

  • Optimized microwave chemistry methodology with ProTide resins
  • Cleanest reaction environment with updated headspace flushing technology
  • More direct optimized flow paths
  • Digitally variable N2 control for optimized bubbling, purging, and draining


The best way to deliver critical reagents.

  • Infinitely variable – deliver whatever volume you want (unlike sample loops)
  • No priming ever
  • No washing and less complex than syringe pumps
High Throughput (HT) Loaders

High Throughput (HT) Loaders

High-throughput peptide synthesis made easy.

  • Automated synthesize of 4 or 12 peptides (individual 20mer’s completed every 1.5 hours)
  • The Liberty Blue 2.0 paired with either the HT4 or the HT12 keeps up with conventional parallel systems


Flexible, Powerful Software

The newly updated software is both flexible and easy to use, making sure nothing stands between you and your synthesis. Customize methods with unique monomers, orthogonal deprotection, branching, cyclizing, and more. Easily check on reactions on the run screen, where the run can be edited, paused, and resumed at any time.

Easy and Flexible Sequence Programming
The method editor on the Liberty Blue allows full customization of reaction parameters.
Program Post-Synthesis Modification
Versatile options enabling orthogonal deprotection for modifications like branching and cyclization.
Edit on the Run
Full Suite of Calculator Tools
Convenient calculators provide the reagents and amounts for a run.
Pause, Edit, Monitor at any Step
Easily pause, edit, and monitor reactions from the run screen.

Do you have any questions? Don´t hesitate to contact us.

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